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Biotechnology Information microarray dataset gse138614
TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( <t>GSE138614</t> ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm
Microarray Dataset Gse138614, supplied by Biotechnology Information, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+datasets/dataset+gse138614+microarray/pmc13123086-29-1-18
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1) Product Images from "TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination"

Article Title: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination

Journal: Journal of Neuroinflammation

doi: 10.1186/s12974-026-03769-4

TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm
Figure Legend Snippet: TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm

Techniques Used: Expressing, Control, Gene Expression, Microarray, Quantitative RT-PCR, Western Blot, Immunofluorescence, Marker

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Article Title: Transcriptional Profiling of <scp>SSEA</scp>‐1<sup>+</sup> Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis
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Expressing:

Article Title: The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4 + T cell tissue infiltration.
Article Snippet: Article The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration Highlights • SUB1 dictates the tissue infiltration of pathogenic CD4+ T cells • Sub1 expression is directly modulated by the TCR-IRF4 pathway • Sub1 deficiency prevents EAE onset by halving DOCK2 levels • SUB1 undergoes LLPS to open chromatin and drive the JUNB-DOCK2 transcriptional cascade Authors Xiaoxue Li, Wenhua Liang, Weifang Wang, Eilon Sherman, Keling Huang, Feng Wang Correspondence wangfeng16@sjtu.edu.cn In brief Blocking pathogenic T cell migration is crucial for treating autoimmune diseases.. Li et al. reveal SUB1 as a gatekeeper of CD4+ T cell infiltration in autoimmunity.. TCR-induced SUB1 drives Rac- dependent cytoskeletal remodeling via DOCK2 transcriptional activation.

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Image Search Results


TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm

Journal: Journal of Neuroinflammation

Article Title: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination

doi: 10.1186/s12974-026-03769-4

Figure Lengend Snippet: TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm

Article Snippet: The microarray dataset GSE138614 was retrieved from the Gene Expression Omnibus (GEO) repository of the National Center for Biotechnology Information ( https://www.ncbi.nlm.nih.gov/geo/ ).

Techniques: Expressing, Control, Gene Expression, Microarray, Quantitative RT-PCR, Western Blot, Immunofluorescence, Marker

SIRT3 is downregulated in RCC. ( A ) Based on the GEO GSE53757 dataset, SIRT3 mRNA levels in RCC tissues were compared with those in normal tissues. ( B ) SIRT3 protein levels in RCC tissues were analyzed in comparison to adjacent normal tissues using CPTAC data. ( C ) SIRT3 protein levels in RCC tissues and normal tissues were detected using immunohistochemistry (IHC). A scatter plot was generated to display the expression of SIRT3 in adjacent normal tissues versus RCC tissues. ( D, E ) Enrichment plots were produced to illustrate the gene expression signatures for proliferation (CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN) and migration (GOBP_ENDOTHELIAL_CELL_MIGRATION). *** P < 0.001.

Journal: Scientific Reports

Article Title: SIRT3 suppresses renal cancer progression by regulating IDH2 acetylation

doi: 10.1038/s41598-026-37783-6

Figure Lengend Snippet: SIRT3 is downregulated in RCC. ( A ) Based on the GEO GSE53757 dataset, SIRT3 mRNA levels in RCC tissues were compared with those in normal tissues. ( B ) SIRT3 protein levels in RCC tissues were analyzed in comparison to adjacent normal tissues using CPTAC data. ( C ) SIRT3 protein levels in RCC tissues and normal tissues were detected using immunohistochemistry (IHC). A scatter plot was generated to display the expression of SIRT3 in adjacent normal tissues versus RCC tissues. ( D, E ) Enrichment plots were produced to illustrate the gene expression signatures for proliferation (CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN) and migration (GOBP_ENDOTHELIAL_CELL_MIGRATION). *** P < 0.001.

Article Snippet: The GSE53757 microarray dataset was obtained through the National Center for Biotechnology Information Gene Expression Omnibus database (NCBI GEO, https://www.ncbi.nlm.nih.gov/gds/?term=GSE53757 ).

Techniques: Comparison, Immunohistochemistry, Generated, Expressing, Produced, Gene Expression, Migration